The future of surgical treatment options in patients with spinal deformities.

Cresco Spine’s ambition (it’s ‘moon shot’) is to establish a new standard in surgical treatment options to cure, rather than salvage scoliotic deformities, using flexible and dynamic implants.

Cresco Spine’s Dynamic Implant Solutions™ consists of a line of dynamic implant systems, based on the “philosophy of the scoliotic disc”.

Preventing fusion, Preserving spinal mobility

The initial deformity in scoliosis, long before the bone becomes deformed, occurs in the intervertebral disc, which makes this the target tissue in scoliosis treatment2,3,4,5.

The mechanism of the development of the scoliotic deformity at a vulnerable stage in the maturing or aging intervertebral disc is different in Early Onset Scoliosis (EOS), Adolescent Idiopathic Scoliosis (AIS) and Degenerative Scoliosis5. However, the possibility of a temporary dynamic and flexible surgical protection of the spine can be similar for all three pathologies.

Internal Bracing

All scoliosis deformities are largely due to passive anterior lengthening of the intervertebral disc and are characterized by a combination of apical rotation, lateral bending and apical lordosis.

It is known that Infantile Scoliosis can be corrected in some cases with casting, reversing the deformity without fusion6.

In older children and adults, the forces that need to be applied are much greater than in infants, but an ‘internal dynamic brace’ could apply sufficient force to correct the spine before permanent changes occur.

After the disc has become stable in the correct and reduced shape, and the vulnerable phase of the disc has passed, chances of progression have become minimal and the internal brace could be removed.

The spine has matured, with the help of this dynamic internal brace, to a reduced and stable configuration without spinal stiffening or fusion.

Double Spring Reduction (DSR™) implant

The DSR™ is a proprietary posterior pedicle screw based implant, consisting of two different spring implants, the torsional spring implant (TSI) and the spring distraction system (SDS™).

The continuous dynamic distraction and de-rotation forces guide the correction of the scoliotic spine while maintaining a normal growth and mobility of the instrumented segment.

The functionality of the DSR™ has been demonstrated in a representative idiopathic-like scoliotic animal model1.

The system is currently in an investigational phase and not available for clinical use.

plant getting assisted with growing

Literature References

1

Justin V.C. Lemans, Sebastiaan P.J. Wijdicks, Gerrit Overweg, Edsko E.G. Hekman, Tom. P.C. Schlösser, Rene M. Castelein, Gijsbertus J. Verkerke, Moyo C. Kruyt. Three-dimensional correction of scoliosis by a double spring reduction system as a dynamic internal brace: a pre-clinical study in Göttingen minipigs. The Spine Journal (2023); 23:599−608.

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2

Theodoros B Grivas, Elias Vasiliadis, Marinos Malakasis, Vasilios Mouzakis, Dimitrios Segos. Intervertebral disc biomechanics in the pathogenesis of idiopathic scoliosis. Stud Health Technol Inform (2006);123:80-3.

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3

Ryan E Will, Ian A Stokes, Xing Qiu, Matthew R. Walker, James O Sanders. Cobb Angle Progression in Adolescent Scoliosis Begins at the Intervertebral Disc. Spine(2009); 34(25): 2782–2786.

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4

I A Stokes and D D Aronsson. Disc and vertebral wedging in patients with progressive scoliosis. J Spinal Disord (2001); 14(4):317-22.

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5

Rene M Castelein, Saba Pasha, Jack CY Cheng, and Jean Dubousset. Idiopathic Scoliosis as a Rotatory Decompensation of the Spine. J Bone Miner Res (2020);35(10):1850-1857.

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6

M H Mehta. Growth as a corrective force in the early treatment of progressive infantile scoliosis. J Bone Joint Surg Br (2005); 87(9):1237-47

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Regulatory

Currently only for use as investigational
device and not available for sale or distribution.

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